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Following the lives of people, each weighing over 600lbs. Through their year-long journeys, they attempt to lose thousands of pounds collectively, to survive.
At over 700lbs, Brianne is on a weight-loss journey to save her own life. But she faces another shock when her husband's health suddenly deteriorates.
Octavia has been bedbound for nearly a year when she gets help. But, with her best friend also her worst enabler, can she choose between old habits and a new life?
Siblings Robin and Chris are both obese and already lost a sibling to obesity. Now, Chris's son Garrett, already 600lbs at age 20, wants to lose weight.
A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food.
Holly already has a failed weight loss surgery, so to succeed she must alter more than her eating habits. Can she overcome the childhood trauma which still haunts her?
Nathan gets a wake-up call when his weight interferes with his job as a drama teacher. But changing his life requires his wife to lose weight, too.
Despite being so big from overeating that she can barely leave the house, Lacey has found love with Ricky. But his interfering sister is complicating things.
Julian's food addiction has led him to weigh more than 800 pounds and left him almost housebound. He faces a battle to lose weight and save his marriage.
Bianca is all in for a move to Houston with her boyfriend to get help with a second weight-loss surgery. But her boyfriend's change of mind could ruin her progress.
Mike gained over 700lbs after his football dreams were dashed by multiple concussions. Now he must find a new purpose in life to avoid succumbing to pain and regret.
James needs to control his love for food in order to survive, but a death in the family sends him retreating back to the comforts he knows.
Living on a homestead with his family, Lucas dreams of working in IT. But all he does is eat and game, and if he wants to lead a normal life, he needs Dr. Now's help.
At 700 pounds, 35-year-old Margaret is virtually bedbound. It's time for her to overcome her food addiction so she can finally live her life.
At 700 pounds, Ontreon's faith in God kept him going, and he's training to become a minister. But if he can't believe in himself, he won't be able to stop eating.
Dolly has gotten too comfortable at 600lbs. She suffers physical pain, and the skin apron pulls on her abdomen, but she avoids taking responsibility for her life.
For Larry, a second weight loss surgery would mean another chance at a career as a gospel recording artist. He must change his eating addiction and take control.
When her boyfriend and enabler falls ill, Lisa turns to Dr. Now for help with her food addiction. Can she summon the determination to turn her life around?
David grew up in foster care and didn't develop a sense of self-worth. Now he weighs 800 pounds and needs to find the motivation to save his own life.
Geno was raised with lots of love and food but now he's living with his mum and eating himself to death. Together, Geno and his cousin pledge to lose weight!
After five years in a scooter, Latonya's weight has made her almost immobile. She doesn't want to give up her food comforts, but will she do it for love?