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Suburban housewife Mary Alice Young takes her own life and finds that, for her, the afterlife consists of watching and commenting on the lives of her friends and family.
Gabrielle goes to great lengths to hide her affair; Lynette tries tough love to discipline the twins; Bree and Rex try marriage counselling.
The four ladies decide to organise the dinner that the late Mary Alice was planning; Karl returns to Wisteria Lane to discuss terms with Susan.
Cash-strapped Mrs Huber works out that Susan had something to do with Edie's house fire. Carlos becomes suspicious that Gabrielle is seeing another man, but targets the wrong suspect.
A break-in on Wisteria Lane leaves the neighbours feeling vulnerable, and Susan reluctantly accepts a date with a persistent policeman after Mike Delfino appears disinterested in her.
Lynette locks horns with an officious mom at the twins' school who is trying to produce a politically correct play about Little Red Riding Hood.' Susan continues to investigate Zach's disappearance.
Susan is miffed when Mike's very sexy house guest Kendra, forces him to postpone their first official date. Lynette becomes more dependant on the twins' attention deficit disorder medication.
The residents of Wisteria Lane take stock of their lives after tragedy; Susan grows suspicious of Mike's reasons for moving to the neighbourhood.
Gabrielle decides to organise a glamorous fashion show for charity; Susan learns Gabrielle's shocking secret; Lynette uses her business acumen to poach a nanny.
Uber mom Maisy Gibbons returns, and her secret life intersects with Bree's. Meanwhile Gabrielle's predicament worsens, Susan plans to take her relationship with Mike to the next level.
Edie organises a neighbourhood search for the missing Mrs Huber, just as the absent busybody's sister arrives on Wisteria Lane. Bree resigns herself to her marital state and asks a pharmacist on a date.
The residents of Wisteria Lane finally learn Martha Huber's fate and the truth has unexpected consequences for Susan. Meanwhile Bree finds her new beau, George, getting a little too close for comfort.
When Lynette's father-in-law pays a visit, she unwittingly learns a family secret, and Susan is disturbed by Julie's growing romance with Zach.
Susan looks forward to a romantic date with Mike until she learns a surprising fact about her favorite plumber; Lynette's cranky old neighbor Kathryn Joosten accuses the Scavo twins of thievery.
Mike Delfino is questioned about Mrs Huber's murder, while John's friend Justin attempts to blackmail Gabrielle with his knowledge of their affair. Meanwhile, Tom wants a big promotion.
Maisy Gibbons' hobby is exposed when she's arrested for prostitution. When news of a black book surfaces, Bree becomes determined to suppress news of Rex's dalliance with the domestic dominatrix.
There's a change in Mama Solis's condition. Lynette befriends a deaf woman whose children also attend Barcliff.Bree encounters trouble with her son and Susan finds herself attracted to Edie's contractor
Susan's mum, Sophie, pays an unannounced visit to Wisteria Lane after she and her boyfriend call it quits. Meanwhile, Gabrielle faces Carlos's wrath after he learns about the settlement.
Lynette discovers that no good deed goes unpunished when she befriends mean Mrs McCluskey, and Susan is mortified when her mum, also newly single - decides to jump start both their love lives.
Some unwelcome faces resurface as George Williams re-enters Bree's life and Lynette discovers that Tom's old girlfriend has been hired at his firm. Gabrielle plans a big party to bid farewell to Carlos.
George Williams continues to worm his way into Bree's life, Lynette tries to spice things up with Tom who, she fears, is losing interest, Gabrielle's latest man troubles grow even more complicated.
Susan makes a decision about Mike Delfino, Lynette takes steps to make sure Annabel doesn't come between her and Tom, Bree comes to a realisation about George the pharmacist.
The housewives have a new neighbour: strict disciplinarian Betty Applewhite, Andrew Van De Kamp has a fight with Justin, who he had been experimenting with sexually.