An attack by cyber criminals sends the Chastain ER into a tailspin and Kit tries to figure out whether or not to pay the ransom. The Raptor deals with a personal connection to the patients brought into the ER during the attack, leaving them all vulnerable.

When one of the doctors is found unconscious in an elevator at Chastain, the staff frantically retraces his steps to figure out the cause. Billie is faced with a personal conflict, while Bell helps Kit make a decision about a new neurosurgeon joining the team.

When an accident brings a familiar patient into the Chastain ER, the doctors must face the reality of figuring out how to proceed with the best care. Meanwhile, The Raptor and Leela deal with a patient returning with the long-term effects of COVID.

In trying to find a way to channel his emotions, Conrad puts all his effort in looking for answers. Raptor has a run-in with the police that ends up taking a surprising turn. Leela begins noticing problems with a surgeon who has been Bell's mentor.

While looking for a distraction on Halloween, Conrad treats a group of witches who send the ER into chaos. Devon treats a patient who thinks he is being haunted. Meanwhile, on the way back from his vacation, Bell picks up a hitchhiker who is not what he seems to be.

Conrad brings a patient into the hospital who causes a high security crisis. An MMA brawl sends a well-known fighter to Chastain and all hands are on deck. Meanwhile, Bell and Raptor vie for the same position at the hospital, and Leela gets a visit from her sister.

A new group of interns start their first day with Devon at Chastain. Kit and Bell try to convince Conrad to come back to Chastain. The Raptor's mother ends up back in the ER. Leela and Padma deal with an unexpected visit from their parents.

Kit hires a surgical coach to watch over Bell and Raptor and help them brush up on their skills. Upon receiving attention from multiple women at the hospital, Conrad contemplates jumping back into the dating scene. Devon works with an elderly couple.

Conrad takes Trevor under his wing to care for a patient whose good luck seems to have run out. Leela struggles when given the decision to take full responsibility of her patient's life. Devon and Kit are stretched too thin trying to balance everything on their plates.

When the first day of Kit's experimental Flight Go team programme sends Conrad out into the field, he builds a new relationship with a fellow doctor along for the ride. Devon works with Trevor for the first time on a patient with a mysterious fever.

A case turns personal for Conrad when the donor recipient of Nic's heart is admitted to the ER. Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision. Meanwhile, the Raptor asks Devon to include his mother in his clinical trial.

A lost child is brought into the ER with physical signs of abuse. While out shopping, Devon and Leela encounter a woman who is having trouble breathing. Meanwhile, Bell eyes an open seat on the State Medical Board and Billie decides it's time to confront her past.

A tragic accident occurs at Jessica's sister's gender reveal party, putting her brother-in-law's life in jeopardy. Meanwhile, Conrad, Irving and Trevor work on an influencer whose life was put in danger by a risky cosmetic surgery.

When things from Billie's past begin to come to light, she is the subject of whispers and stares around the hospital and the team struggles to find the best way to support her. With the nurse shortage in full swing, a simple cleaning job turns into a horrific disaster.

As his clinical begins, Devon treats his first patient with a revolutionary medical fluid that doesn't go as planned. Meanwhile, an overdosed John Doe is rushed to Chastain, leading Conrad straight into a much bigger scandal than he expected.

Conrad and The Raptor help out a friend whose heart problems reveal a bigger issue than they expected. Devon treats a suicidal woman whom he thinks might be a candidate for Deep Brain Stimulation. Bell confronts the Medical Board about the cases he's been investigating.

Conrad treats one of Gigi's fellow classmates, whose stomach ache turns into something much more serious. Meanwhile, Devon takes several interns to a senior living facility, where they meet a former doctor whose wife falls ill during their visit.

When Conrad confronts a pharmacy owner about fraudulent prescriptions being filled under his name, the situation takes a dangerous turn. Then, the ER is sent into chaos when a street racing accident results in multiple severe injuries.

With Raptor on leave to take care of his mother, the hospital scrambles to stay organised without him. A camping trip leaves a patient with a fatal disease that none of the doctors have seen before. Bell and Kit devise a plan to help their case with the Medical Board.

Conrad and Cade work with a Medicare patient who sheds some light on the inner workings of the prescription fraud situation. Meanwhile, Leela works herself to the brink of exhaustion to avoid having a conversation with Devon and eventually makes mistakes on her cases.

When one of the doctors is shot outside the hospital, the ER is put into lockdown and the team races to save one of their own. Elsewhere, Devon and The Raptor work with a patient who learns he is unable to receive a lung transplant, due to his vaccination status.

When a young boy comes into the hospital with a rare disease which leaves his bones incredibly fragile, Cade's father scrubs in to assist in the surgery, leaving Cade all on her own in her recovery. Devon has some huge decisions to make about the future of his career.

Conrad contemplates his future as he reminisces about a special night. Meanwhile, Devon is presented with an amazing career opportunity out of state, and Ian is faced with a devastating diagnosis, which causes him to rely on the doctors at Chastain.