Popularly known as Dr Pimple Popper, dermatologist Sandra Lee treats individuals afflicted with unusual skin conditions.
Gabriel has a huge growth on his clavicle but is terrified of surgery. Karen has dealt with painful, scaly feet for 22 years with no diagnosis.
Ruben is a personal trainer whose head growth has prevented him from seeing clients. Kaitlin has blue marks and scars due to long-term drug use.
Margarita is a matriarch who has been hiding her armpit lump from her family. Bradley has a concerning growth that looks like raw meat on his leg.
Jeremy is a pastor with a hanging growth in an embarrassing location. Todd has a bump protruding from his forehead that is painful and humiliating.
Jason lost confidence and motivation due to the large growth on his neck. Shawnell has multiple mystery bumps on her head that have destroyed her self-esteem.
Roger has a considerable growth on his shoulder that he calls his "second head." Jenna is a bubbly teenager with an even bigger bubble behind her ear.
Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times.
Former cruise ship worker Julie hopes Dr. Lee can remove her large back growth. And, JD is a gentle giant with a pear-shaped mass hanging off his ear.
Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good. Justice has small lesions all over her body that get inflamed.
Debra has a large, brainlike growth on the side of her head that feels like a sponge, has crevices and emits an odour. Cowboy Dusten has painful lump on his knee.
Brittany has been called a monster due to a genetic condition that causes head-to-toe bumps. Tamyra has skin so thick she shaves the bottom of her feet for relief.
Jaclyn has a lump on the back of her head that causes her emotional distress. Shane has a growth between his eyes that could put him in danger at his electrician job.
Robert has thousands of unique bumps on his arms that Dr. Lee has never seen. Stuart's cluster of back bumps disgusts his wife but thrills Dr. Lee.
Stacey's shoulder growth prevents her from being the playful teacher she once was. Matthew worries that his mysterious shin rash may be dangerous.
Elaine calls the growth on her love handle her third breast. Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove.
Covered in bumps, Keke is embarrassed to be intimate with her husband. Corey has been labelled a devil worshipper because of his forehead growth.
Monica returns in the hopes that Dr. Lee can remove more of her face growths. Ken has several large cysts on his head that he has tried to remove on his own.
Terry's nose growth has prevented him from meeting his grandkids. And, Remi has alligator-like skin and is not used to taking care of herself.
Roger has huge growths on his nose that drip pus, attract flies and make breathing difficult. Plus, two sisters share many undiagnosed face bumps.
'Tis the season for squeezing and Dr. Lee's patients are popping with presents. Patients include Santa impersonator Tim, who has a huge neck growth.
Roger returns and hope Dr. Lee can help with his gigantic nose growths. Christine has lost her essence due to a large growth on her shoulder.
Angelina's huge chest lump affects her love life and Delano has a football-sized mass on his back. Plus, Carla hopes to get painful cysts removed from her scalp.
Melissa covered her huge lipoma with a sweatshirt for years. Tyler's fear of cancer stopped his head lumps being diagnosed and Tahj is covered in painful boils.
Half of Mary's body is a size 18 while the other is an 8. Anthony's cyst is in the area called the Triangle of Death, and Shane wants to get a lump off his back.
Belinda's lump on her neck causes her to be immobile. Nicole won't get married until she gets her arm pit lump removed. And, Nick unwisely removed a lipoma at home.
The large bump at the base of Taylor's spine is more dangerous than she realizes. John has an embarrassing hip lump, and Noelle wants her stretched ears repaired.
Louis is covered in scaly skin that makes him feel like an alligator. Jennifer can't focus on her career due to a large unicorn-like lump on her forehead.
Patrick's nose is covered by huge bumps and he can barely breathe. Matt has suffered from neurofibromatosis his entire life and is in incredible pain.
April is covered in bumps that have disfigured her arms. And, Genner has flown all the way from the Philippines to have Dr. Lee help with his bumpy nose.
Matt has a skin condition that causes tumours to grow all over his body. Plus, Jennifer has a unicorn bump on her forehead.
Amber has hundreds of tumors on her face. Sisters Cheri and Janice suffer from possibly matching lumps. Tatiana has an embarrassing bump on her butt cheek.
Lisa fears the horn growing out of the back of her head could be cancer. Chuck has a Popeye-shaped bump on his arm, and two teen brothers have matching lumps.
Dr. Sandra Lee treats Taylore, a young woman with unsightly elf-like bumps on her ears. Jose never goes out because of the baseball-sized lump on his head.
Josh has a large knot on his head sustained from a car crash 18 years ago. Brittney is covered in mysterious bumps. TJ has a curious lump protruding from his side.
Barbara's back lump became more noticeable after she lost 131 pounds. Hilda's depression is a result of the multitude of bumps on her eyelids.
Leonard has a bump hanging off his arm that looks like it's breaking through skin. Jess has a visible lump on her butt after falling downstairs.
Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar. And, Paul has a giant hump on his back.
Rhonda has bumps all over her head, including a worrying horned growth. And, Dr. Lee treats Kevin, who has a huge lump protruding from his hip.
Jen has growths on her ears that cause her depression, pain and vertigo. Plus, Juliet is in distress because of the bumps all over her neck and chest.
Gerald returns to see Dr. Lee and a hand specialist about a huge, intrusive bump on his finger. Vinnie has an embarrassing birthmark on his neck.
Gerard has nearly a hundred lumps varying in size all over his body. Eric has a large bump on his head that he calls his "on/off button.
Traci's confidence was destroyed after years of bullying about the bumps that have plagued her face for 20 years. Ravon has a unique dangling growth on his leg.
David is back to see Dr. Lee after she spotted a suspicious growth under his eye. And, Alan has a growth on his bicep but is terrified of doctors.
Tim has a massive growth on his back that affects his ability to work and socialise. Meanwhile, a mother-daughter duo has bonded over their bumps.
Inoke has a huge and potentially life-threatening bulge on his shoulder. Delano returns to see Dr. Lee and Reed has hundreds of bumps all over his chest.
With pandemic safety protocols in place, Dr. Lee reopens her office. Patients include Monica, who has a large birthmark growing on the side of her face.
Dr. Lee treats Reginald, who has a rare growth on the back of his head. Che'Re has a prominent bump on her face, and Juan has painful boils on his neck.
Dennis has several giant growths on his head. Juan has a rare condition he hopes Dr. Lee will understand. Natalie is covered in hundreds of mysterious dark bumps.
Audrey pops the painful bumps on her body so she can feel relief. Krista's excessive sweating is so severe that she could fill up an entire milk jug with her sweat.
John fears the large lump on his neck could become so big that it may eventually suffocate him. Shoshana is depressed because of the big growth on her forehead.
Twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak. Matt, a former Marine, has a large recurring lump in his armpit.
Shakisaha split her left earlobe after stretching it with gauges. Mike is a tough guy with a soft bump on his head, and Dania's rhinophyma kept her from enjoying life.
Ed wants his stomach lump removed before his girlfriend gets out of prison. And, James has a large, squishy lump on his forehead.
Dr. Lee faces off with iguana-wrangler Madison's head growths. Chanel suffers from painful cyst tunnels that leak and smell like the food she eats.
Bob suffers from mysterious open-wound sores all over his body. Virginia can't wait to have her lump removed. Tom is desperate to find a cure for his itchy skin.
Steven's bump is so large, his daughter thinks he is growing a monster on his back. Ethan suffers from an irritating rash in an awkward place on his body.
John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps on her arms, chest, and belly.
Casey's birthmark covers most of her face, head, and neck. Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.
Aimee has a mohawk of cysts on her head. Plus, Edith's face markings and itchy skin condition turn out to be more than she expected.
Elizabeth's head is covered with giant cauliflower-shaped bumps. Jamaal has been growing a strange knob on his bottom since he was just a boy.
Dr. Lee and her staff are swamped once again before Christmas! Wesley asks for help with a questionable growth under his eye that makes him feel like Rudolph.
Christmas is in full swing at HQ! Dr. Lee and her staff re-create classic Christmas movies with a pimple-y twists for holiday cards for their patients.
Dr. Sandra Lee is one of America's top dermatologists and a YouTube sensation. She treats patients with unusual skin conditions one pop at a time.